The biodegradable polymer framework, combined with cell therapy, creates optimal conditions for nerve tissue regeneration, according to the press service. Mechanically similar to spinal cord tissue, the scaffold provides structural support for cells during recovery, offering a potential breakthrough for spinal cord therapy.
Spinal cord injuries remain one of the most challenging medical conditions due to the limited regenerative capacity of the adult central nervous system, the scientists mention. Cell therapy shows promise but faces obstacles such as low cell survival and difficulty controlling transplanted cells. According to the Sirius team, biomaterials like the new scaffold can act as a supportive matrix for cells and guide axon growth, creating a favorable environment for neuron regeneration.
Laboratory tests show that the scaffold increases neuron density fivefold, demonstrating its ability to foster nerve growth. The research is part of an interdisciplinary project combining the university’s Neurobiology and Biomaterials departments.
Researchers hope the scaffold could eventually form the basis for next-generation implants to treat spinal cord injuries.